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Product Information
Description | Claudin 1 rabbit polyclonal |
Protein full name | Claudin-1 |
Synonyms | CLDN1, CLD1, ILVASC, SEMP1, claudin 1 |
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse claudin-1 |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location |
Cell junction, Cell membrane, Basolateral cell membrane |
Uniprot ID | O88551 |
Applications
Applications | Species | Dilution | Positive Tissue |
IHC | Mouse, Rat | 1: 200-1: 800 | liver,lung,colon |
IF | Mouse, Rat | 1: 400-1: 800 | liver,lung,colon |
Background
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
Images
Immunohistochemistry analysis of paraffin-embedded mouse liver using Clauind 1(GB11032) at dilution of 1: 400 |
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Immunohistochemistry analysis of paraffin-embedded mouse colon using Clauind 1 (GB11032) at dilution of 1: 400 |
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Immunohistochemistry analysis of paraffin-embedded mouse lung using Clauind 1 (GB11032) at dilution of 1: 400 |
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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