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Anti -N Cadherin Rabbit pAb

價格: 在線咨詢
貨號:
DRF101124
產(chǎn)品規(guī)格:
100 μL
Applications:
Species:
購買數(shù)量:
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產(chǎn)品詳情 操作說明 注意事項

Product Information


Description

N Cadherin rabbit polyclonal

Protein full name

Cadherin-2

Synonyms

Neural cadherin, N-cadherin, CD325, CDw325,

Cadherin 2 N cadherin neuronal, CDHN, Cdh2,

Cadherin 2 type 1, NCAD, N cadherin 1

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse N Cadherin

Isotype

IgG

Purity

Affinity purification

Predicted MW.

100 kDa

Observed MW.

140 kDa

Uniprot ID

P19022, P15116, Q9Z1Y3




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

muscle, testis




Background


N-cadherin (neuronal cadherin; or CDH2/cadherin 2) is a calcium-binding, single pass transmembrane cell adhesion molecule (CAM) that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. N-cadherin's function is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of beta-catenin. Further, N-cadherin is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry.




Images


image.png

Western blot analysis of N Cadherin (GB111009) at dilution of 1: 1000

Lane 1: A549 cell lysate

Lane 2: MCF7 cell lysate

Lane 3: SKOV3 cell lysate

Lane 4: Mouse muscle tissue lysate

Lane 5: Mouse testis tissue lysate

Lane 6: Rat muscle tissue lysate

Lane 7: Rat testis tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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