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Anti -ADAMTS1 Rabbit pAb

價(jià)格: 在線咨詢
貨號:
DRF101126
產(chǎn)品規(guī)格:
100 μL
Applications:
WB
Species:
M/R
購買數(shù)量:
產(chǎn)品詳情 操作說明 注意事項(xiàng)

Product Information


Description

ADAMTS1 rabbit polyclonal

Protein full name

A disintegrin and metalloproteinase with thrombospondin motifs 1

Synonyms

ADAMTS1, ADAMTS, METH1. KIAA1346, A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 1, ADAM metallopeptidase with thrombospondin type 1 motif 1

Immunogen

KLH conjugated Synthetic peptide corresponding to Human ADAMTS1

Isotype

IgG

Purity

Affinity purification

Predicted MW.

106 kDa

Observed MW.

110 kDa

Uniprot ID

P97857, Q9WUQ1




Applications


Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1: 500-1: 1000

heart, brain




Background


ADAMTS1 (a disintegrin and metalloproteinase with thrombospondin motifs 1), is the founding member of the family of secreted zinc proteases with a multidomain structure. The protein precursor consists of a signal peptide and the following domains: pro, catalytic, disintegrinlike, TS type 1 motif, cysteine rich, spacer and a variable number of thrombospondin type 1 motifs. Based on their substrate specificity, ADAMTS1 and associated family members may be key enzymes in the degradation of cartilage leading to inflammation and arthritis. It is an active protease cleaving alpha 2 macroglobulin, aggrecan and versican. ADAMTS1 is essential for normal growth and the structure and function of the kidneys, adrenal glands and female reproductive organs. It also plays an important role in atherosclerosis.




Images


image.png

Western blot analysis of ADAMTS1(GB111011) at dilution of 1: 1000

Lane 1: Mouse heart tissue lysate

Lane 2: Mouse brain tissue lysate

Lane 3: Rat heart tissue lysate

Lane 4: Rat brain tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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