Anti -Cytokeratin 1 Rabbit pAb

價格：在線咨詢

貨號：

DRF101132

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	Cytokeratin 1 rabbit polyclonal
Protein full name	Keratin, type II cytoskeletal 1
Synonyms	67 kDa cytokeratin, Cytokeratin-1, Keratin-1, CK-1, K1, Type-II keratin Kb1, Krt1, Krt2-1, EHK1, Keratin type II cytoskeletal 1
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse Cytokeratin 1
Isotype	IgG
Purity	Affinity purification
Predicted MW.	66 kDa
Observed MW.	66 kDa
Uniprot ID	P04264, P04104, Q6IMF3

Applications

Applications	Species	Dilution	Positive Tissue
WB	Human, Mouse, Rat	1: 500-1: 1000	skin

Background

Cytokeratin 1 is a heterotetramer of two type I as well as two type II keratins localized in the cell membrane and is generally associated with keratin-10 . It has been suggested to regulate the activity of kinases such as PKC/SRC via binding to integrin beta-1 and the receptor of activated protein kinase C. Cytokeratin 1 and its heterodimer partner KRT10 are the major constituents of 4 intermediate filament cytoskeleton in suprabasal epidermis/keratinocytes, and their upregulation precedes expression of filaggrin and cornified envelope proteins. Covalent crosslinking of cytokeratin 1 but not of KRT10 to these proteins, in addition to a complex series of lipids, ultimately forms the cornified/lipid envelope, that constitutes the epidermal barrier together with Langerhans cells. Defects in cytokeratin 1 have been linked to epidermolytic hyperkeratosis (EHK), ichthyosis hystrix Curth-Macklin type (IHCM), palmoplantar keratoderma non-epidermolytic (NEPPK), ichthyosis annular epidermolytic (AEI), palmoplantar keratoderma striate type 3 (SPPK3).

Images

Western blot analysis of Cytokeratin 1 (GB111017) at dilution of 1: 1000

Lane 1: A375 cell lysate

Lane 2: PANC-1 cell lysate

Lane 3: Mouse skin tissue lysate

Lane 4: Rat skin tissue lysate

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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