Anti -MEKK3 Rabbit pAb

價(jià)格：在線咨詢

貨號：

DRF101136

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

H/M/R

品牌：

萬物

購買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	MEKK3 rabbit polyclonal
Protein full name	Mitogen-activated protein kinase kinase kinase 3
Synonyms	MAPK/ERK kinase kinase 3, MEK kinase 3, MEKK 3, Map3k3, Mekk3
Immunogen	Recombinant protein corresponding to Mouse MEKK3
Isotype	IgG
Purity	Affinity purification
Predicted MW.	71 kDa
Observed MW.	78 kDa
Uniprot ID	Q99759, Q61084, B5DF98

Applications

Applications	Species	Dilution	Positive Tissue
WB	Human, Mouse, Rat	1: 800-1: 1000	liver, lung

Background

The mitogen-activated protein/ERK kinase kinase 3 (MEKK3) is a member of a family of MEKK/Ste11 serine/threonine protein kinases. One function of MEKK3 is to serve as an upstream regulatory kinase in the mitogen activated protein kinase cascade, however, it also plays a critical role in other signaling pathways. MEKK3 regulates several important functions including cell survival and proliferation. It is ubiquitously expressed in multiple tissues and has been found in complexes with scaffold proteins and other kinases.Cerebral cavernous malformations (CCMs) complex regulation of MEKK3 is essential during vertebrate heart development. MEKK3 signalling and KLF2/4 may be targeted to develop new CCM therapeutics.

Images

Western blot analysis of MEKK3 (GB111020) at dilution of 1: 1000

Lane 1: Hela cell lysate

Lane 2: HepG2 cell lysate

Lane 3: Jurkat cell lysate

Lane 4: Mouse liver tissue lysate

Lane 5: Rat liver tissue lysate

Lane 6: Rat lung tissue lysate

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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