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Anti -Src Rabbit pAb

價(jià)格: 在線咨詢
貨號(hào):
DRF101152
產(chǎn)品規(guī)格:
100 μL
Applications:
IHC/IF
Species:
H/M/R,H/M/R
購(gòu)買數(shù)量:
產(chǎn)品詳情 操作說(shuō)明 注意事項(xiàng)

Product Information


Description

Src rabbit polyclonal

Protein full name

Neuronal proto-oncogene tyrosine-protein kinase Src

Synonyms

SRC, ASV, SRC1, c-p60-Src, SRC proto-oncogene, non receptor tyrosine kinase, THC6

Immunogen

Recombinant protein corresponding to Mouse Src

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cell membranem, Cytoplasm, Nucleus

Uniprot ID

P12931, P05480, Q9WUD9




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Human, Mouse, Rat

1: 1000-1: 4000

breast cancer, brain, small intestine

IF

Human, Mouse, Rat

1: 500-1: 1000

breast cancer, brain, small intestine




Background


SRC, also named as SRC1 and p60-Src, belongs to the protein kinase super family, Tyr protein kinase family and SRC subfamily. It is a non-receptor protein tyrosine kinase that plays pivotal roles in numerous cellular processes such as proliferation, migration, and transformation. In concert with PTK2B, SRC plays an important role in osteoclastic bone resorption. It promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase. This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.




Images


image.png

Immunohistochemistry analysis of paraffin-embedded human breast cancer  using Src (GB111035) at dilution of 1: 2000

image.png

Immunohistochemistry analysis of paraffin-embedded mouse brain using Src (GB111035) at dilution of 1: 2000

image.png

Immunohistochemistry analysis of paraffin-embedded mouse small intestine using Src (GB111035) at dilution of 1: 2000

image.png

Immunohistochemistry analysis of paraffin-embedded rat brain using Src (GB111035) at dilution of 1: 2000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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