Anti -CARM1 Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

DRF101153

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

M/R,M/R

品牌：

萬物

購(gòu)買數(shù)量：

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產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	CARM1 rabbit polyclonal
Protein full name	Histone-arginine methyltransferase CARM1
Synonyms	Prmt4, Protein arginine N-methyltransferase 4, PRMT 4, Coactivator-associated arginine methyltransferase 1, Carm1
Immunogen	Recombinant protein corresponding to Mouse CARM1
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cytoplasm, Nucleus
Uniprot ID	Q9WVG6, Q4AE70

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Mouse, Rat	1: 800-1: 2000	brain
IF	Mouse, Rat	1: 400-1: 800	brain

Background

CARM1, also named as PRMT4, belongs to the protein arginine N-methyltransferase family. It is a dual functional coregulator that facilitates transcription initiation by methylation of Arg17 and Arg26 of histone H3 and also dictates the subsequent coactivator complex disassembly by methylation of the steroid receptor coactivator family coactivators and p300/cAMP-response element-binding protein. CARM1 functions as a coactivator for many nuclear receptors, such as oestrogen receptor, androgen receptor, thyroid receptor and farnesoid X-receptor. It also coactivates other transcription factors such as myocyte enhancer factor 2C (MEF2C), β-catenin, p53, nuclear factor (NF)-kB and the cAMP-responsive element-binding factor. The enzymatic activity and coactivator function of CARM1 has been found to be inactivated through phosphorylation at a conserved serine residue at mitosis stage.

Images

	Immunohistochemistry analysis of paraffin-embedded mouse brain using CARM1 (GB111036) at dilution of 1: 1000
	Immunohistochemistry analysis of paraffin-embedded rat brain using CARM1 (GB111036) at dilution of 1: 1000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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