Anti -NFkB p100/NFKB2 Rabbit pAb

價(jià)格：在線咨詢

貨號：

DRF101173

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

H/M/R

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	NFKB2 rabbit polyclonal
Protein full name	Nuclear factor NF-kappa-B p100 subunit
Synonyms	DNA-binding factor KBF2, Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2, Nuclear factor NF-kappa-B p52 subunit, Nfkb2, Lyt10, H2TF1
Immunogen	Recombinant protein corresponding to Human NFKB2
Isotype	IgG
Purity	Affinity purification
Predicted MW.	97 kDa
Observed MW.	110 kDa
Uniprot ID	Q00653, Q9WTK5, Q5U2Z4

Applications

Applications	Species	Dilution	Positive Tissue
WB	Human, Mouse, Rat	1: 500-1: 1000	lung, spleen, stomach

Background

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. NFKB2 appears to have dual functions such as cytoplasmic retention of attached NF-kappa-B proteins by p100 and generation of p52 by a cotranslational processing. The proteasome-mediated process ensures the production of both p52 and p100 and preserves their independent function. P52 binds to the kappa-B consensus sequence 5'-GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. P52 and p100 are respectively the minor and major form; the processing of p100 being relatively poor.

Images

Western blot analysis of NFKB2 (GB111053) at dilution of 1: 1000

Lane 1: Jurkat cell lysate

Lane 2: Hela cell lysate

Lane 3: NIH/3T3 cell lysate

Lane 4: Mouse lung tissue lysate

Lane 5: Mouse spleen tissue lysate

Lane 6: Mouse stomach tissue lysate

Lane 7: Rat lung tissue lysate

Lane 8: Rat spleen tissue lysate

Lane 9: Rat stomach tissue lysate

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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