Anti -KMT1B / SUV39H2 Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

DRF101174

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

H/M/R,H/M/R

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	SUV39H2 rabbit polyclonal
Protein full name	Histone-lysine N-methyltransferase SUV39H2
Synonyms	Histone H3-K9 methyltransferase 2, KMT1B, H3-K9-HMTase 2, Lysine N-methyltransferase 1B, Suppressor of variegation 3-9 homolog 2, Su(var)3-9 homolog 2, SUV39H2
Immunogen	Recombinant protein corresponding to Mouse SUV39H2
Isotype	IgG
Purity	Affinity purification
Subcellular location	Nucleus
Uniprot ID	Q9H5I1

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Human, Mouse, Rat	1: 1000-1: 4000	breast cancer
IF	Human, Mouse, Rat	1: 500-1: 3000	breast cancer

Background

Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher order chromatin organization during spermatogenesis.

Images

Immunohistochemistry analysis of paraffin-embedded human breast cancer using SUV39H2 (GB111054) at dilution of 1: 2000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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