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Product Information
Description |
ICAM 1 rabbit polyclonal |
Protein full name |
Intercellular adhesion molecule 1 |
Synonyms |
ICAM1, BB2, CD54, P3.58, intercellular adhesion molecule 1 |
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse ICAM-1 |
Isotype |
IgG |
Predicted MW. |
58 kDa |
Observed MW. |
58 kDa |
Purity |
Affinity purification |
Subcellular location |
|
Uniprot ID |
Applications
Applications |
Species |
Dilution |
Positive Tissue |
WB |
Human, Mouse |
1: 1000-1: 3000 |
kidney, liver,lung |
IHC |
Mouse, Rat |
1: 800-1: 6000 |
liver, kidney |
IF |
Mouse, Rat |
1: 500-1: 1000 |
lung |
Background
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). During leukocyte trans-endothelial migration, ICAM1 engagement promotes the assembly of endothelial apical cups through ARHGEF26/SGEF and RHOG activation.
(Microbial infection) Acts as a receptor for major receptor group rhinovirus A-B capsid proteins . Acts as a receptor for Coxsackievirus A21 capsid proteins . Upon Kaposis sarcoma-associated herpesvirus/HHV-8 infection, is degraded by viral E3 ubiquitin ligase MIR2, presumably to prevent lysis of infected cells by cytotoxic T-lymphocytes and NK cell .
Images
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Western blot analysis of ICAM 1 (GB11106) at dilution of 1: 1000 Lane 1: Mouse liver tissue lysate Lane 2: Mouse lung +LPS tissue lysate Lane 3: Mouse kidney tissue lysate |
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Immunohistochemistry analysis of paraffin-embedded mouse kidney ICAM 1 (GB11106) at dilution of 1: 1500 |
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Immunohistochemistry analysis of paraffin-embedded rat kidney ICAM 1 (GB11106) at dilution of 1: 1500 |
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Immunohistochemistry analysis of paraffin-embedded mouse liver ICAM 1 (GB11106) at dilution of 1: 1500
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Immunofluorescence analysis of paraffin-embedded mouse lung using ICAM 1 (GB11106) at dilution of 1: 500
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Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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