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Product Information
Description |
JAM-A rabbit polyclonal |
Protein full name |
Junctional adhesion molecule A |
Synonyms |
JAM-A, Junctional adhesion molecule 1, JAM-1, CD321, F11r, Jam1, Jcam, Jcam1 |
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse JAM-A |
Isotype |
IgG |
Purity |
Affinity purification |
Predicted MW. |
33 kDa |
Observed MW. |
35 kDa |
Uniprot ID |
Applications
Applications |
Species |
Dilution |
Positive Tissue |
WB |
Human, Mouse, Rat |
1: 500-1: 1000 |
liver, colon, small intestine |
Background
Seems to play a role in epithelial tight junction formation. Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin super family gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as a receptor for reovirus, a ligand for the integrin LFA1, involved in leukocyte transmigration, and a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established.
Images
Western blot analysis of JAM-A (GB111062) at dilution of 1: 1000 Lane 1: Caco2 cell lysate Lane 2: SW480 cell lysate Lane 3: Mouse liver tissue lysate Lane 4: Mouse colon tissue lysate Lane 5: Rat liver tissue lysate Lane 6: Rat small intestine tissue lysate |
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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