Anti -KAT5 / Tip60 Rabbit pAb

價(jià)格：在線咨詢

貨號：

DRF101186

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

H/M/R,H/M/R

品牌：

萬物

購買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	Tip60 rabbit polyclonal
Protein full name	Histone acetyltransferase KAT5
Synonyms	60 kDa Tat-interactive protein, Tip60, Histone acetyltransferase HTATIP, Kat5, Lysine acetyltransferase 5, Htatip, Tip60
Immunogen	Recombinant protein corresponding to Mouse Tip60
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cytoplasm, Nucleus
Uniprot ID	Q92993, Q8CHK4, Q99MK2

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Human, Mouse, Rat	1: 1000-1: 2000	lung cancer, breast cancer, brain, heart
IF	Human, Mouse, Rat	1: 500-1: 3000	lung cancer, breast cancer, brain, heart

Background

Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation.

Images

	Immunohistochemistry analysis of paraffin-embedded human lung cancer using Tip60 (GB111065) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded human breast cancer tumor using Tip60 (GB111065) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded mouse brain using Tip60 (GB111065) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded rat brain using Tip60 (GB111065) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded rat heart using Tip60 (GB111065) at dilution of 1: 2000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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