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Anti -MLK4 Rabbit pAb

價格: 在線咨詢
貨號:
DRF101193
產(chǎn)品規(guī)格:
100 μL
Applications:
WB
Species:
M/R
購買數(shù)量:
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產(chǎn)品詳情 操作說明 注意事項

Product Information


Description

MLK4 rabbit polyclonal

Protein full name

Mitogen-activated protein kinase kinase kinase 21

Synonyms

Mitogen-activated protein kinase kinase kinase MLK4, Mixed lineage kinase 4, Map3k21, Kiaa1804, Mlk4

Immunogen

Recombinant protein corresponding to Mouse MLK4

Isotype

IgG

Purity

Affinity purification

Predicted MW.

110 kDa

Observed MW.

120 kDa

Uniprot ID

Q8VDG6, D4A454




Applications


Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1: 500-1: 1000

heart




Background


MLK4 belongs to the MAP kinase subfamily. The MLK family members are characterized by the presence of signature sequences of Ser/Thr and Tyr kinases within their catalytic domain. The MLK1-4 contains an aminoterminal Src-Homology (SH3) domain, followed by the kinase domain, a leucine-zipper region, and a Cdc42/Rac-interactive binding (CRIB) motif. MLK4 expressed in two splicing variants, MLK4α and MLK4β. The difference of these two isoforms is located in their C-terminal portion. The negative effect of MLK4 on LPS-induced ERK and JNK activation could be very important in controlling the level of cytokine expression, and thus maintaining the balance of inflammatory responses.




Images


Western blot analysis of MLK4 (GB111071) at dilution of 1: 1000
Lane 1: Mouse heart tissue lysate
Lane 2: Rat heart tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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