Anti -PTPN12 Rabbit pAb

價格：在線咨詢

貨號：

DRF101198

產(chǎn)品規(guī)格：

100 μL

Applications：

WB/IHC/IF

Species：

H/M/R,H/M/R,H/M/R

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	PTPN12 rabbit polyclonal
Protein full name	Tyrosine-protein phosphatase non-receptor type 12
Synonyms	Protein-tyrosine phosphatase P19, Ptpn12, MPTP-PEST, P19-PTP
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse PTPN12
Isotype	IgG
Purity	Affinity purification
Predicted MW.	88 kDa
Observed MW.	110 kDa
Subcellular location	Cytoplasm
Uniprot ID	Q05209, P35831, G3V7Q4

Applications

Applications	Species	Dilution	Positive Tissue
WB	Human, Mouse, Rat	1: 500-1: 800	lung, ovary, testis
IHC	Human, Mouse, Rat	1: 1000-1: 3000	lung cancer, brain, ovary, lung
IF	Human, Mouse, Rat	1: 500-1: 2000	lung cancer, brain, ovary, lung

Background

The PTPN12 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. The PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion. This suggests it has a regulatory role in controlling cell shape and mobility.

Images

	Western blot analysis of PTPN12 (GB111076) at dilution of 1: 1000 Lane 1: SW480 cell lysate Lane 2: MCF7 cell lysate Lane 3: Mouse lung tissue lysate Lane 4: Mouse ovary tissue lysate Lane 5: Mouse testis tissue lysate Lane 6: Rat lung tissue lysate Lane 7: Rat ovary tissue lysate
	Immunohistochemistry analysis of paraffin-embedded human lung cancer using PTPN12 (GB111076) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded mouse brain using PTPN12 (GB111076) at dilution of 1:2000
	Immunohistochemistry analysis of paraffin-embedded mouse ovary using PTPN12 (GB111076) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded mouse lung using PTPN12 (GB111076) at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded rat lung using PTPN12 (GB111076) at dilution of 1: 2000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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