The Tollip is the component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates
Images
Western blot analysis of NCR1 (GB111102) at dilution of 1: 1000
Lane 1: Mouse brain tissue lysate
Lane 2: Mouse spleen tissue lysate
Lane 3: Mouse thymus tissue lysate
Lane 4: Mouse brain tissue lysate
Lane 5: Mouse spleen tissue lysate
Lane 6: Mouse thymus tissue lysate
Immunohistochemistry analysis of paraffin-embedded human liver cancer using Tollip (GB111093) at dilution of 1: 2000
Immunohistochemistry analysis of paraffin-embedded mouse spleen using Tollip (GB111093) at dilution of 1: 2000
Immunohistochemistry analysis of paraffin-embedded rat kidney using Tollip (GB111093) at dilution of 1: 2000
Immunohistochemistry analysis of paraffin-embedded rat brain using Tollip (GB111093) at dilution of 1: 2000
Immunohistochemistry analysis of paraffin-embedded rat lung using Tollip (GB111093) at dilution of 1: 2000
Storage
Storage
Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .