Anti -BRCA2 Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

DRF101262

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

M/R,M/R

品牌：

萬(wàn)物

購(gòu)買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說(shuō)明注意事項(xiàng)

Product Information

Description	BRCA2 rabbit polyclonal
Protein full name	Breast cancer type 2 susceptibility protein
Synonyms	Brca2, BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, Breast cancer 2, DNA repair associated, breast cancer 2, Early onset, BRCA2 DNA repair associated
Immunogen	Recombinant protein corresponding to Mouse BRCA2
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cytoplasm, Nucleus
Uniprot ID	P97929, O35923

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Mouse, Rat	1: 1500-1: 3000	brain
IF	Mouse, Rat	1: 1500-1: 3000	brain

Background

BRCA2, also named as FACD and FANCD1, is involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures.Defects in BRCA2 are a cause of genetic susceptibility to breast cancer (BC) which also called susceptibility to familial breast-ovarian cancer type 2 (BROVCA2).

Images

	Immunohistochemistry analysis of paraffin-embedded mouse brain using BRCA2 (GB111138) at dilution of 1: 2200
	Immunohistochemistry analysis of paraffin-embedded rat brain using BRCA2 (GB111138) at dilution of 1: 2200
	Immunofluorescent analysis of paraffin-embedded mouse brain using BRCA2 (GB111138) at dilution of 1: 2200
	Immunofluorescent analysis of paraffin-embedded rat brain using BRCA2 (GB111138) at dilution of 1: 2200
	Immunofluorescent analysis of paraffin-embedded mouse brain using BRCA2 (GB111138) at dilution of 1: 2200

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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