Anti -CDKN2A/p16INK4a Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

DRF101268

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

H,H

品牌：

萬物

購買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	CDKN2A rabbit polyclonal
Protein full name	Cyclin-dependent kinase inhibitor 2A
Synonyms	Cyclin-dependent kinase 4 inhibitor A, CDK4I, p16-INK4a, Cdkn2a, P16ink4a
Immunogen	Recombinant protein corresponding to Mouse CDKN2A
Isotype	IgG
Purity	Affinity purification
Subcellular location	Nucleus
Uniprot ID	P51480, Q9R0Z3

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Human	1: 500-1: 2000	lung cancer, ovarian cancer, breast cancer, colon
IF	Human	1: 500-1: 1000	breast, colon

Background

This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.

Images

	Immunohistochemistry analysis of paraffin-embedded human lung cancer using CDKN2A (GB111143) at dilution of 1: 1000
	Immunohistochemistry analysis of paraffin-embedded human ovarian cancer using CDKN2A (GB111143) at dilution of 1: 1000
	Immunohistochemistry analysis of paraffin-embedded human breast cancer using CDKN2A (GB111143) at dilution of 1: 1000
	Immunohistochemistry analysis of paraffin-embedded human colon using CDKN2A (GB111143) at dilution of 1: 1000
	Immunofluorescent analysis of paraffin-embedded human breast using CDKN2A (GB111143) at dilution of 1: 1000
	Immunofluorescent analysis of paraffin-embedded human colon using CDKN2A (GB111143) at dilution of 1: 1000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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