Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity).
Images
Western blot analysis of CD163 (GB11340) at dilution of 1:1200.
Lane 1:MH-S cell lysate
Lane 2:Raw264.7 cell lysate
Lane 3:Mouse spleen tissue lysate
Lane 4:Mouse lung tissue lysate
Lane 5:Mouse lymph nodes tissue lysate
Lane 6:Rat lung tissue lysate
Western blot analysis of CD163 (GB11340) at dilution of 1:1200.
Lane 1:SH-SY5Y cell lysate
Lane 2:THP-1 cell lysate
Lane 3:Raw264.7 cell lysate
Storage
Storage
Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .