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Product Information
Description |
BIK rabbit polyclonal antibody |
Protein full name |
Inward rectifier potassium channel 2 |
Synonyms |
Inward rectifier K(+) channel Kir2.1, IRK-1, Potassium channel, inwardly rectifying subfamily J member 2, Kcnj2, Irk1 |
Immunogen |
Recombinant protein corresponding to Mouse BIK |
Isotype |
IgG |
Purity |
Affinity purification |
Predicted MW. |
48 kDa |
Observed MW. |
55 kDa |
Uniprot ID |
P35561, Q64273 |
Applications
Applications |
Species |
Dilution |
Positive Sample |
WB |
Mouse, Rat |
1: 500-1: 1000 |
brain |
Background
KCNJ2,
also named as HHBIRK1, HHIRK1, IRK1, KIR2.1, LQT7 and SQT3, belongs to
the inward rectifier-type potassium channel family. KCNJ2 probably
participates in establishing action potential waveform and excitability
of neuronal and muscle tissues. Inward rectifier potassium channels are
characterized by a greater tendency to allow potassium to flow into the
cell rather than out of it. Their voltage dependence is regulated by the
concentration of extracellular potassium; as external potassium is
raised, the voltage range of the channel opening shifts to more positive
voltages. The inward rectification is mainly due to the blockage of
outward current by internal magnesium. KCNJ2 can be blocked by
extracellular barium or cesium. Defects in KCNJ2 are the cause of long
QT syndrome type 7 (LQT7). Defects in KCNJ2 are the cause of short QT
syndrome type 3 (SQT3).
Images
|
Western blot analysis of KIR2.1 (GB111433) at dilution of 1: 500 |
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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