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Product Information
Description |
CRMP3 rabbit polyclonal antibody |
Protein full name |
Dihydropyrimidinase-related protein 4 |
Synonyms |
DRP-4, Collapsin response mediator protein 3, CRMP-3, UNC33-like phosphoprotein 4, ULIP-4, Dpysl4, Crmp3, Ulip4 |
Immunogen |
Recombinant protein corresponding to Mouse CRMP3 |
Isotype |
IgG |
Purity |
Affinity purification |
Subcellular location |
Cytoplasm |
Uniprot ID |
O35098, Q62951 |
Applications
Applications |
Species |
Dilution |
Positive Sample |
IHC/IF |
Human, Mouse, Rat |
1: 600-1: 3000 |
brain, cervical cancer, epencephalon, laryngocarcinoma, ovary |
Background
CRMP-3 is expressed transiently in developing spinal cord and selectively in the postnatal cerebellum. It is cleaved by Calpain to produce a p54 N-terminal fragment. This cleavage product translocates to the nucleus and induces neuronal death in response to excitotoxicity and cerebral ischemia. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.
Images
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Immunohistochemistry of paraffin embedded mouse brain using CRMP3 (GB112592) at dilution of 1:650 (400x lens) |
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Immunohistochemistry of paraffin embedded mouse epencephalon using CRMP3 (GB112592) at dilution of 1:650 (400x lens) |
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Immunohistochemistry of paraffin embedded rat brain using CRMP3 (GB112592) at dilution of 1:650 (400x lens) |
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Immunohistochemistry of paraffin embedded rat epencephalon using CRMP3 (GB112592) at dilution of 1:650 (400x lens) |
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Immunofluorescence of paraffin embedded human cervical cancer using CRMP3 (GB112592) at dilution of 1:650 (400x lens) |
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Immunofluorescence of paraffin embedded human laryngocarcinoma using CRMP3 (GB112592) at dilution of 1:650 (400x lens) |
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Immunofluorescence of paraffin embedded mouse brain using CRMP3 (GB112592) at dilution of 1:650 (400x lens) |
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Immunofluorescence of paraffin embedded mouse ovary using CRMP3 (GB112592) at dilution of 1:650 (400x lens) |
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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