Anti -TrkB Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

KT011727

產(chǎn)品規(guī)格：

100ul

Applications：

IHC/IF

Species：

M/R,M/R

品牌：

萬物

購(gòu)買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	TrkB rabbit polyclonal
Protein full name	BDNF/NT-3 growth factors receptor
Synonyms	NTRK2, GP145-TrkB, TRKB, trk-B, neurotrophic receptor tyrosine kinase 2, OBHD
Immunogen	Recombinant protein corresponding to Mouse TrkB
Isotype	IgG
Subcellular location	Cell membrane, Endosome membrane, Early endosome membrane
Purity	Affinity purification
Uniprot ID	P15209, Q63604

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Mouse, Rat	1: 500-1: 4000	brain, spinal marrow
IF	Mouse, Rat	1: 500-1: 1000	brain, spinal marrow

Background

Tropomyosin receptor kinase B is the high affinity catalytic receptor for several "neurotrophins", which are small protein growth factors that induce the survival and differentiation of distinct cell populations. The neurotrophins that activate TrkB are: BDNF (Brain Derived Neurotrophic Factor), neurotrophin-4 (NT-4), andneurotrophin-3 (NT-3). As such, TrkB mediates the multiple effects of these neurotrophic factors, which includes neuronal differentiation and survival. Research has shown that activation of the TrkB receptor can lead to down regulation of the KCC2 chloride transporter in cells of the CNS.

Images

	Immunohistochemistry analysis of paraffin-embedded rat brain using TrkB (GB11295-2) at dilution of 1: 500
	Immunohistochemistry analysis of paraffin-embedded mouse brain using TrkB (GB11295-2) at dilution of 1: 500
	Immunohistochemistry analysis of paraffin-embedded mouse spinal marrow using TrkB (GB11295-2) at dilution of 1: 1000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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