Anti -TSC-1 Rabbit pAb

價格：在線咨詢

貨號：

DRF101666

產品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數量：

立即詢價在線咨詢 400-1016-218

產品詳情操作說明注意事項

Product Information

Description	TSC-1 rabbit polyclonal
Protein full name	Hamartin
Synonyms	Tsc1, TSC1, LAM, TSC, tuberous sclerosis 1, TSC complex subunit 1, TSC-1
Immunogen	Recombinant protein corresponding to Mouse TSC-1
Isotype	IgG
Purity	Affinity purification
Predicted MW.	128 kDa
Observed MW.	128 kDa
Uniprot ID	Q9Y258

Applications

Applications	Species	Dilution	Positive Tissue
WB	Human	1: 500-1: 1000	PC3, Jurkat, 293T

Background

Tuberous sclerosis 1 (TSC1), also known as hamartin, is a protein encoded by the TSC1 gene. TSC1 functions as a co-chaperone which inhibits the ATPase activity of the chaperone Hsp90 (heat shock protein-90) and decelerates its chaperone cycle. Tsc1 functions as a facilitator of Hsp90 in chaperoning the kinase and non-kinase clients including Tsc2, therefore preventing their ubiquitination and degradation in the proteasome. TSC1, TSC2 and TBC1D7 is a multi-protein complex also known as the TSC complex. This complex negatively regulates mTORC1 signaling by functioning as a GTPase-activating protein (GAP) for the small GTPase Rheb, an essential activator of mTORC1. The TSC complex has been implicated as a tumor suppressor.

Images

Western blot analysis of TSC-1

(GB11882) at dilution of 1: 1000

Lane 1: PC3 cell lysate

Lane 2: Jurkat cell lysate

Lane 3: 293T cell lysate

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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