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Product Information
Description | TAU rabbit polyclonal |
Protein full name | Microtubule-associated protein tau |
Synonyms | Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, DDPAC, FTDP 17, MAPTL, RNPTAU, PPP1R103, Paired helical filament-tau |
Immunogen |
KLH conjugated Synthetic peptide corresponding to Human TAU |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Cytoplasm, Cell membrane |
Predicted MW. | 79 kDa |
Observed MW. | 50-80 kDa |
Uniprot ID | P10636, P10637, P19332 |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Human, Mouse, Rat | 1: 2000-1: 4000 | brain, cortex, spinal cord, hippocampus |
IHC | Human, Mouse | 1: 3000-1: 5000 | gliomas, brain |
Background
Tau is a neuronal microtubule-associated protein found predominantly on axons. The function of Tau is to promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome.
Images
Western blot analysis of TAU (GB111608) at dilution of 1: 2000 Lane 1: Human glioma cell lysate Lane 2: Mouse brain tissue lysate Lane 3: Mouse cortex tissue lysate Lane 4: Mouse hippocampus tissue lysate Lane 5: Mouse spinal cord tissue lysate Lane 6: Rat brain tissue lysate Lane 7: Rat cortex tissue lysate Lane 8: Rat hippocampus tissue lysate |
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Immunohistochemistry analysis of paraffin-embedded human gliomas using TAU (GB111608) at dilution of 1: 3000 |
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Immunohistochemistry analysis of paraffin-embedded mouse brain using TAU (GB111608) at dilution of 1: 3000 |
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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