Anti -SHP2 Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

KT011669

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

R/R

品牌：

萬(wàn)物

購(gòu)買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說(shuō)明注意事項(xiàng)

Product Information

Description	SHP2 rabbit polyclonal
Protein full name	Tyrosine-protein phosphatase non-receptor type 11
Synonyms	SHP2, PTPN11, BPTP3, CFC, JMML, METCDS, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, Protein tyrosine phosphatase, non-receptor type 11
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse SHP2
Isotype	IgG
Purity	Affinity purification
Subcellular location	Nucleus
Uniprot ID	P35235

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Rat	1: 1000-1: 2000	lung, colon
IF	Rat	1: 500-1: 1000	lung, colon

Background

PTPN11 is a protein tyrosine phosphatase (PTP) Shp2. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains two tandem Src homology-2 domains, which function as phospho-tyrosine binding domains and mediate the interaction of this PTP with its substrates. This PTP is widely expressed in most tissues and plays a regulatory role in various cell signaling events that are important for a diversity of cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration. Mutations in this gene are a cause of Noonan syndrome as well as acute myeloid leukemia.

Images

Immunohistochemistry analysis of paraffin-embedded rat lung using

SHP2 (GB11698) at dilution of 1: 1000

Immunohistochemistry analysis of paraffin-embedded rat colon using

SHP2 (GB11698) at dilution of 1: 1000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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