Villin 1 (VIL1) is a 95-kd F-actin bundling and severing protein and its expression is restricted to epithelial cells with a brush border, like epithelial cells of the intestinal mucosa, gall bladder, renal proximal tubules and ductuli efferentes of the testis. VIL1 has been reported to be an epithelial cell-specific anti-apoptotic protein, and to have an important function in regulating actin dynamics, cell morphology, epithelial-to-mesenchymal transitions, cell migration and cell survival. In addition, VIL1 is a useful diagnostic marker for of various cancer, like cervical and endometrial adenocarcinomas, renal cell carcinoma. VIL1 was recently identified as a novel biomarker predictive for postoperative recurrence and poorer prognosis of high serum AFP associated HCC.
Images
Western blot analysis of villin (GB111209) at dilution of 1: 1000
Immunohistochemistry of paraffin embedded human colon using villin (GB111209) at dilution of 1: 1500 (400x lens)
Immunohistochemistry of paraffin embedded mouse kidney using villin (GB111209) at dilution of 1: 1500 (400x lens)
Immunohistochemistry of paraffin embedded rat gall bladder using villin (GB111209) at dilution of 1: 1500 (400x lens)
Immunohistochemistry of paraffin embedded rat small intestine using villin (GB111209) at dilution of 1: 1500 (400x lens)
Immunofluorescence of paraffin embedded human colon using villin (GB111209) at dilution of 1: 1500 (400x lens)
Immunofluorescence of paraffin embedded mouse kidney using villin (GB111209) at dilution of 1: 1500 (400x lens)
Immunofluorescence of paraffin embedded rat gall bladder using villin (GB111209) at dilution of 1: 1500 (400x lens)
Immunofluorescence of paraffin embedded rat small intestine using villin (GB111209) at dilution of 1: 1500 (400x lens)
Storage
Storage
Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .