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Anti -MRP1 Rabbit pAb

價格: 在線咨詢
貨號:
KT011987
產(chǎn)品規(guī)格:
100 μL
Applications:
IHC/IF
Species:
R/R
購買數(shù)量:
立即詢價 在線咨詢 400-1016-218
產(chǎn)品詳情 操作說明 注意事項

Product Information


Description

MRP1 rabbit polyclonal

Protein full name

Multidrug resistance-associated protein 1

Synonyms

ATP-binding cassette sub-family C member 1, Leukotriene C(4) transporter, Abcc1, Mrp1, LTC4 transporter

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse MRP1

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cell membrane

Uniprot ID

Q8CG09




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Rat

1: 800-1: 1600

lymphoid, brain

IF

Rat

1: 400-1: 800

lymphoid, brain




Background


MRP1 is a member of the MRP subfamily of ATPbindingcassette (ABC) transporters . MRP1 protein functions as an organic anion transporter. It has a broad range of substrates, including antineoplastic or therapeutic agent sand the glutathione (GSH) conjugates of these compounds. MRP1 also transports physiological substrates such as folates, GSH and GSH disulfide (GSSG) conjugates of steroids,leukotrienes and prostaglandins. Although MRP1 is generally expressed in normaltissue, upregulation of MRP1 has been found in avariety of solid tumors, including small cell lung cancer, breast cancer, and prostate cancer . Research studies show that over expression of MRP1 facilitates the elimination of therapeutic agents from cancer cells and confers drug resistance in those patients. Research studies also show that elevated expression of MRP1 is a negative prognostic marker for breast cancer and small cell lung cancer, as the level of MRP1 is predictive of the response and toxicity of chemotherapeutic agents in those patients.




Images


image.png

Immunohistochemistry analysis of paraffin-embedded rat lymphoid usingMRP1 (GB111041) at dilution of 1: 1600

image.png

Immunohistochemistry analysis of paraffin-embedded rat brain using MRP1 (GB111041) at dilution of 1: 1600




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .


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