Ctsk, Procathepsin K, Cathepsin K, Cathepsin O, Cathepsin X, CTSO
Immunogen
Recombinant protein corresponding to Mouse Cathepsin K
Isotype
IgG
Purity
Affinity purification
Subcellular location
Cytoplasm
Uniprot ID
P55097, O35186
Applications
Applications
Species
Dilution
Positive Sample
IHC/IF
Mouse, Rat
1: 1000-1: 2000
bone
Background
The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis an autosomal recessive disease characterized by osteosclerosis and short stature.
Images
Immunohistochemistry of paraffin embedded mouse bone using Gathepsin-K (GB111276) at dilution of 1:2200 (400x lens)
Immunohistochemistry of paraffin embedded rat bone using Gathepsin-K (GB111276) at dilution of 1:2200 (400x lens)
Storage
Storage
Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).