Recombinant protein corresponding to Human Inhibin alpha
Isotype
IgG
Purity
Affinity purification
Subcellular location
Secreted
Uniprot ID
P17490
Applications
Applications
Species
Dilution
Positive Sample
IHC/IF
Rat
1: 900-1: 1800
brain, lung, spleen
Background
The
inhibin alpha subunit joins either the beta A or beta B subunit to form
a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate
gonadal stromal cell proliferation negatively and to have
tumour-suppressor activity. In addition, serum levels of inhibin have
been shown to reflect the size of granulosa-cell tumors and can
therefore be used as a marker for primary as well as recurrent disease.
However, in prostate cancer, expression of the inhibin alpha-subunit
gene was suppressed and was not detectable in poorly differentiated
tumor cells. Furthermore, because expression in gonadal and various
extragonadal tissues may vary severalfold in a tissue-specific fashion,
it is proposed that inhibin may be both a growth/differentiation factor
and a hormone.
Images
Immunohistochemistry of paraffin embedded rat brain using Inhibin-Alpha (GB111221) at dilution of 1:900 (400x lens)
Immunohistochemistry of paraffin embedded rat lung using Inhibin-Alpha (GB111221) at dilution of 1:900 (400x lens)
Immunohistochemistry of paraffin embedded rat spleen using Inhibin-Alpha (GB111221) at dilution of 1:900 (400x lens)
Storage
Storage
Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).