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- 郵箱：355185756@qq.com
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Anti -HMGB1 Rabbit pAb
價格：
在線咨詢
貨號：
KT012135
產(chǎn)品規(guī)格：
100 μL
Applications：
WB/IHC/IF
Species：
HMR/HMR
購買數(shù)量：
產(chǎn)品詳情
操作說明
注意事項
Product Information
|
Description |
HMGB1 rabbit polyclonal antibody |
|
Protein full name |
High mobility group protein B1 |
|
Synonyms |
HMGB1, HMG1, HMG3, SBP-1, HMG-1, high mobility group box 1 |
|
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse HMGB1 |
|
Isotype |
IgG |
|
Purity |
Affinity purification |
|
Subcellular location |
Nucleus, Cytoplasm, Secreted, Cell membrane |
|
Predicted MW. |
25 kDa |
|
Observed MW. |
25 kDa |
|
Uniprot ID |
P09429, P63158, P63159 |
Applications
|
Applications |
Species |
Dilution |
Positive Sample |
|
WB |
Human, Mouse, Rat |
1: 500-1: 1000 |
nasopharyngeal carcinoma, liver, cancer, kidney, colon cancer |
|
IHC/IF |
Human, Mouse, Rat |
1: 300-1: 3000 |
brain, breast cancer, colon cancer, kidney, skin, spinal cord |
Background
Like the histones, HMGB1 is among the most important chromatin proteins. In the nucleus HMGB1 interacts withnucleosomes, transcription factors, and histones. This nuclear protein organizes the DNA and regulates transcription.After binding, HMGB1 bendsDNA, which facilitates the binding of other proteins. HMGB1 supports transcription of many genes in interactions with many transcription factors. It also interacts with nucleosomes to loosen packed DNA and remodel the chromatin. Contact with core histones changes the structure of nucleosomes.
Images
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|
Western blot analysis of HMGB1 (GB11103) at dilution of 1: 500 |
|
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Immunohistochemistry of paraffin embedded human breast cancer using HMGB1 (GB11103) at dilution of 1: 3000 (300x lens) |
|
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Immunohistochemistry of paraffin embedded human breast cancer using HMGB1 (GB11103) at dilution of 1: 3000 (300x lens) |
|
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Immunohistochemistry of paraffin embedded mouse brain using HMGB1 (GB11103) at dilution of 1: 3000 (300x lens) |
|
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Immunohistochemistry of paraffin embedded mouse kidney using HMGB1 (GB11103) at dilution of 1: 3000 (300x lens) |
|
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Immunohistochemistry of paraffin embedded rat skin using HMGB1 (GB11103) at dilution of 1: 2000 (300x lens) |
|
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Immunohistochemistry of paraffin embedded rat spinal cord using HMGB1 (GB11103) at dilution of 1: 2000 (300x lens) |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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合肥萬物生物科技有限公司
客服熱線：400-1016-218
QQ：355185756
地址：安徽省合肥市高新區(qū)黃山路602號合肥國家大學(xué)科技園A401室