Anti -S100A9 Rabbit pAb

價格：在線咨詢

貨號：

KT012257

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

H,H

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	S100A9 rabbit polyclonal
Protein full name	Protein S100-A9
Synonyms	Calgranulin-B, Calprotectin L1H subunit, Leukocyte L1 complex heavy chainMRP-14, p14, S100 calcium-binding protein A9, S100A9, CAGB, CFAG, MRP14
Immunogen	KLH conjugated Synthetic peptide corresponding to Human S100A9
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cell membrane, Secreted
Uniprot ID	P06702

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Human	1: 1000-1: 2000	colon, colon cancer
IF	Human	1: 500-1: 1000	colon, colon cancer

Background

S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K/AKT, and ERK1/2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8/A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include: facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities.Can act as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread.

Images

	Immunohistochemistry analysis of paraffin-embedded human colon using S100A9 at dilution of 1: 2000
	Immunohistochemistry analysis of paraffin-embedded human colon cancer using S100A9 (GB111079) at dilution of 1: 2000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

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