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Product Information
Description |
N Cadherin mouse monoclonal |
Protein full name |
Cadherin-2 |
Synonyms |
Neural cadherin, N-cadherin, CD325, CDw325, Cadherin 2 N cadherin neuronal, CDHN, Cdh2, Cadherin 2 type 1, NCAD, N cadherin 1 |
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse N-cadherin |
Isotype |
IgG |
Subcellular location |
Membrane |
Predicted MW. |
100 kDa |
Observed MW. |
140 kDa |
Purity |
Affinity purification |
Subcellular location |
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Uniprot ID |
Applications
Applications |
Species |
Dilution |
Positive Tissue |
WB |
Human, Mouse, Rat |
1: 1000-1: 2000 |
colon, brain, cerebral cortex |
IHC |
Human, Mouse, Rat |
1: 1000-1: 2000 |
colon |
IF |
Human, Mouse, Rat |
1: 500-1: 1000 |
colon |
Background
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence. CDH2 may be involved in neuronal recognition mechanism. In hippocampal neurons, may regulate dendritic spine density.
Images
Western blot analysis of N Cadherin (GB12135) at dilution of 1: 1000 |
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Immunohistochemistry analysis of paraffin-embedded human colon using N Cadherin (GB12135) at dilution of 1: 1500
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Immunohistochemistry analysis of paraffin-embedded mouse colon using N Cadherin (GB12135) at dilution of 1: 1500 |
Immunohistochemistry analysis of paraffin-embedded rat colon using N Cadherin (GB12135) at dilution of 1: 1500 |
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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