Anti -Tyrosine Hydroxylase Mouse mAb

價格：在線咨詢

貨號：

DRF101 367

產品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

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產品詳情操作說明注意事項

Product Information

Description	Tyrosine Hydroxylase mouse monoclonal
Protein full name	Tyrosine 3-monooxygenase
Synonyms	TH, Th, DYT14, DYT5b, TYH, tyrosine hydroxylase, Tyrosine hydroxylase
Immunogen	Recombinant protein corresponding to Mouse Tyrosine Hydroxylase
Isotype	IgG
Purity	Affinity purification
Subcellular location	cytoplasm, axon
Uniprot ID	P24529,P04177

Applications

Applications	IHC	IF
Species	Mouse,Rat	Mouse,Rat
Dilution	1:1000-1:3000	1:500-1:2000
Positive tissue	Brain, substantia nigra	Mouse striatum

Background

Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to L-3,4-dihydroxyphenylalanine (L-DOPA). It does so using molecular oxygen(O2), as well as iron (Fe2+) and tetrahydrobiopterin as cofactors. L-DOPA is a precursor for dopamine, which, in turn, is a precursor for the important neurotransmitters norepinephrine (noradrenaline) and epinephrine(adrenaline). Tyrosine hydroxylase catalyzes the rate limiting step in this synthesis of catecholamines. In humans, tyrosine hydroxylase is encoded by the TH gene,and the enzyme is present in the central nervous system (CNS), peripheral sympathetic neurons and the adrenal medulla.Tyrosine hydroxylase, phenylalanine hydroxylase and tryptophan hydroxylase together make up the family of aromatic amino acid hydroxylases(AAAHs).

Images

	Immunofluorescence analysis of paraffin-embedded rat brain using Tyrosine Hydroxylase (GB12181) at dilution of 1:1000
	Immunohistochemistry analysis of paraffin-embedded rat substantia nigra using Tyrosine Hydroxylase (GB12181) at dilution of1:3000
	Immunohistochemistry analysis of paraffin-embedded mouse striatum using Tyrosine Hydroxylase (GB12181) at dilution of 1:3000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer.

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