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Product Information
Description |
Connexin 43 / GJA1 mouse monoclonal |
Protein full name |
Gap junction alpha-1 protein |
Synonyms |
GJA1, AVSD3, CMDR, CX43, EKVP, GJAL, HLHS1, HSS, ODDD, PPKCA, gap junction protein alpha 1 |
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse Connexin 43 |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. |
43 kDa |
Observed MW. |
43 kDa |
Subcellular location |
Cell membrane, Cell junction,Endoplasmic reticulum |
Uniprot ID |
Applications
Applications |
IHC |
IF |
Species |
Mouse, Rat |
Mouse, Rat |
Dilution |
1: 300-1: 600 |
1: 150- 1: 300 |
Positive tissue |
heart |
heart |
Background
Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract . May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles .
Images
Immunofluorescence analysis of paraffin-embedded mouse heart using Connexin 43 (GB12234) at dilution of 1: 600 |
|
Immunofluorescence analysis of paraffin-embedded rat heart using Connexin 43 (GB12234) at dilution of 1: 600 |
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer.
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