Anti -ATG3 Mouse mAb

價格：在線咨詢

貨號：

DRF101426

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	ATG3 mouse monoclonal
Protein full name	Ubiquitin-like-conjugating enzyme ATG3
Synonyms	Autophagy-related protein 3, Protein PC3-96, APG3-like, hApg3, ATG3, APG3, APG3L
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse ATG3
Isotype	IgG
Purity	Affinity purification
Predicted MW.	36 kDa
Observed MW.	40 kDa
Uniprot ID	Q9NT62, Q9CPX6, Q6AZ50

Applications

Applications	Species	Dilution	Positive Tissue
WB	Human, Mouse, Rat	1: 500-1: 1000	heart, muscle, kidney

Background

ATG3 (APG3) is a widely expressed conjugating enzyme for APG8 lipidation, an essential step for the initiation of autophagy. Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. Autophagy is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein APG1. ATG3 functions as an E2-like enzyme during the initial stages of autophagosome formation by catalyzing the formation of the Atg8-phosphatidylethanolamine (Atg8-PE) conjugate, which is critical for autophagy.

Images

圖片 1.png

Western blot analysis of ATG3 (GB12839)

at dilution of 1: 1000

Lane 1: K562 cell lysate

Lane 2: THP-1 cell lysate

Lane 3: HeLa cell lysate

Lane 4: Mouse heart tissue lysate

Lane 5: Mouse muscle tissue lysate

Lane 6: Mouse kidney tissue lysate

Lane 7: Rat heart tissue lysate

Lane 8: Rat muscle tissue lysate

Lane 9: Rat kidney tissue lysate

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer	PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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