Anti -P53 Mouse mAb

價格：在線咨詢

貨號：

DRF101436

產(chǎn)品規(guī)格：

50 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項

Product Information

Description	P53 mouse monoclonal
Protein full name	Cellular tumor antigen p53
Synonyms	TP53, BCC7, LFS1, P53, TRP53, tumor protein p53
Immunogen	KLH conjugated Synthetic peptide corresponding to Human P53
Isotype	IgG
Purity	Affinity purification
Subcellular location	Nucleus, Endoplasmic reticulum, Mitochondrion
Uniprot ID	P04637

Applications

applications	species	dilution	Positive tissue
IHC	Human	1: 100-1: 200	lung cancer
IF	Human	1: 100-1: 200	colon cancer

Background

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to effect on cell-cycle regulation. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression.

Images

Immunohistochemistry analysis of paraffin-embedded human lung cancer using P53 (GB13029-3) at dilution of 1:200.

Immunofluorescence analysis of paraffin-embedded human colon cancer using P53 (GB13029-3) at dilution of 1:200.

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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