Anti -CREB Mouse mAb

價格：在線咨詢

貨號：

DRF101449

產(chǎn)品規(guī)格：

50 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項

Product Information

Description	CREB mouse monoclonal
Protein full name	Cyclic AMP-responsive element-binding protein 1
Synonyms	CREB1, CREB, CREB-1, cAMP responsive element binding protein 1
Immunogen	KLH conjugated Synthetic peptide corresponding to Human CREB-1.
Isotype	IgG
Purity	Affinity purification
Predicted MW.	37 kDa
Observed MW.	37 kDa
Uniprot ID	P16220, Q01147, P15337

Applications

applications	species	dilution	Positive tissue
WB	Human, Mouse, Rat	1: 500-1: 1000	spleen, lung, brain

Background

Cyclic AMP Response Element Binding protein (CREB) is a basic / leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation occurs via p44 / 42 MAP kinase and p90RSK and also via p38 MAP kinase and MSK 1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB appears to play an important role in learning and memory. CREB knock out mice show diminished learning ability.

Images

Western blot analysis of CREB (GB13236-1) at dilution of 1: 1000.

Lane 1: HeLa cell lysate

Lane 2: HepG2 cell lysate

Lane 3: NIH3T3 cell lysate

Lane 4: Mouse spleen tissue lysate

Lane 5: Mouse lung tissue lysate

Lane 6: Mouse brain tissue lysate

Lane 7: Rat spleen tissue lysate

Lane 8: Rat lung tissue lysate

Lane 9: Rat brain tissue lysate

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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