Anti -CD86 Rabbit mAb

價格：在線咨詢

貨號：

DRF101457

產(chǎn)品規(guī)格：

50 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	CD86 rabbit monoclonal
Protein full name	CD86
Synonyms	Activation B7-2 antigen, CD28LG2, CTLA-4 counter-receptor B7.2 2
Immunogen	Monoclonal antibody is produced by immunizing animals with mouse CD86 recombinant protein.
Isotype	IgG
Purity	Protein A purified
Subcellular location	Membrane
Predicted MW.	60Da
Observed MW.	85 kDa
Uniprot ID	P42082

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Mouse	1: 100-1: 400	liver, lung
IF	Mouse	1: 100-1: 400	liver, lung

Background

CD80 (B7-1, BB1) and CD86 (B7-2, B70) are members of the B7 family of cell surface ligands that regulate T cell activation and immune responses. CD80 is expressed on activated antigen presenting cells, including dendritic cells, B cells, monocytes, and macrophages. CD86 is expressed on resting monocytes, dendritic cells, activated B lymphocytes, and can be further upregulated in the presence of inflammation (1-3). CD80 and CD86 are ligands for CD28, which functions as a T cell costimulatory receptor. Interaction of CD28 with CD80 or CD86 provides the second signal required for na?ve T cell activation, T cell proliferation, and acquisition of effector functions (3-7). Alternatively, CD80 and CD86 also act as ligands to CTLA-4, which results in the downregulation of T cell activity (3,7-9).

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer	PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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