Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity.
Images
Immunohistochemistry analysis of paraffin-embedded mouse liver using CD45(GB11066) at dilution of 1: 1500
Immunohistochemistry analysis of paraffin-embedded mouse spleen using CD45(GB11066) at dilution of 1: 1500
Immunohistochemistry analysis of paraffin-embedded mouse lung using CD45(GB11066) at dilution of 1: 1500
Immunofluorescent analysis of paraformaldehyde-fixed mouse lymph node inflammation using CD31 (GB11063-2) at dilution of 1: 800
Storage
Storage
Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer
PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .