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Product Information
Description |
CD42b rabbit polyclonal |
Protein full name |
Platelet glycoprotein Ib alpha chain |
Synonyms |
GP-Ib alpha, GPIb-alpha, GPIbA, Glycoprotein Ibalpha, CD42b, BDPLT3, GLYCOCALICIN, VWDP, DBPLT3, CD42b-alpha |
Immunogen |
KLH conjugated Synthetic peptide corresponding to Mouse CD42b |
Isotype |
IgG |
Purity |
Affinity purification |
Subcellular location |
Cell membrane |
Uniprot ID |
Applications
Applications |
Species |
Dilution |
Positive Tissue |
IHC |
Rat |
1: 500-1: 1800 |
lung, spleen |
Background
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease.
Images
|
Immunohistochemistry analysis of paraffin-embedded rat lung using CD42b (GB112044) at dilution of 1: 1800 |
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Immunohistochemistry analysis of paraffin-embedded rat spleen using CD42b (GB112044) at dilution of 1: 1800 |
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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