Anti -CD14 Rabbit pAb

價格：在線咨詢

貨號：

DRF101839

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

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產(chǎn)品詳情操作說明注意事項

Product Information

Description	CD14 rabbit polyclonal
Protein full name	Monocyte differentiation antigen CD14
Synonyms	CD14, entrez:929, CD14 molecule
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse CD14
Isotype	IgG
Predicted MW.	40 kDa
Observed MW.	45 kDa
Purity	Affinity purification
Subcellular location	Cell membrane, Secreted, Membrane raft, Golgi apparatus
Uniprot ID	P08571, P10810, Q63691

Applications

applications	species	dilution	Positive tissue
WB	Human, Mouse, Rat	1:500-1:1000	spleen, thymus gland
IHC	Human, Mouse, Rat	1:500-1:1000	tonsil, Inflammatory lung

Background

Coreceptor for bacterial lipopolysaccharide . In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) . Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response . Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Binds electronegative LDL (LDL-) and mediates the cytokine release induced by LDL-.

Images

圖片 2.png

Western blot analysis of CD14(GB11254) at dilution of 1:1000.

Lane 1:Raw264.7 cell lysate

Lane 2:Jurkat cell lysate

Lane 3:Mouse spleen tissue lysate

Lane 4:Mouse thymus gland tissue lysate

Lane 5:Rat spleen tissue lysate

Lane 6:Rat thymus gland tissue lysate

Lane7:Rat lymph node tissue lysate

Immunohistochemistry analysis of paraffin-embedded mouse lung using CD14(GB11254) at dilution of 1:1000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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