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Product Information
Description |
CD163 rabbit polyclonal |
Protein full name |
Scavenger receptor cysteine-rich type 1 protein M130 |
Synonyms |
CD163, M130, MM130, SCARI1, CD163 molecule |
Immunogen |
Recombinant protein corresponding to Mouse CD163 |
Isotype |
IgG |
Purity |
Affinity purification |
Predicted MW. |
125 kDa |
Observed MW. |
145 kDa |
Uniprot ID |
Q2VLH6, Q86VB7 |
Applications
applications |
species |
dilution |
Positive tissue |
WB |
Human, Mouse, Rat |
1: 1200-1: 1500 |
spleen, lung, lymph nodes |
Background
Involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1 (By similarity).
Images
|
Western blot analysis of CD163 (GB11340) at dilution of 1:1200. Lane 1:MH-S cell lysate Lane 2:Raw264.7 cell lysate Lane 3:Mouse spleen tissue lysate Lane 4:Mouse lung tissue lysate Lane 5:Mouse lymph nodes tissue lysate Lane 6:Rat lung tissue lysate |
Western blot analysis of CD163 (GB11340) at dilution of 1:1200. Lane 1:SH-SY5Y cell lysate Lane 2:THP-1 cell lysate Lane 3:Raw264.7 cell lysate |
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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