Anti -CD45 Rabbit pAb

價格：在線咨詢

貨號：

DRF101869

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	CD45 rabbit polyclonal
Protein full name	Receptor-type tyrosine-protein phosphatase C
Synonyms	PTPRC, B220, CD45, CD45R, GP180, L-CA, LCA, LY5, T200, protein tyrosine phosphatase, receptor type C
Immunogen	Recombinant protein corresponding to human CD45.
Isotype	IgG
Purity	Affinity purification
Predicted MW.	147 KDa
Observed MW.	180 KDa
Uniprot ID	P08575, P06800

Applications

applications	species	dilution	Positive tissue
WB	Human, Mouse	1:500-1:1000	THP-1, thymus, lymph gland

Background

PTPRC is also known as CD45 antigen, which was originally called leukocyte common antigen (LCA). The encoded protein is a member of the protein tyrosine phosphatase (PTP) family. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP, specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling. It also suppresses JAK kinases and functions as a negative regulator of cytokine receptor signaling.

Images

Western blot analysis of CD45 at dilution of 1:1000.

Lane 1: Jurkat cell lysate

Lane 2: Raw264.7 cell lysate

Lane 3: THP-1 cell lysate

Lane 4: Mouse thymus tissue lysate

Lane 5: Mouse lymph gland tissue lysate

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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