Anti -CD40 Rabbit pAb

價格：在線咨詢

貨號：

DRF101877

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	CD40 rabbit polyclonal
Protein full name	Tumor necrosis factor receptor superfamily member 5
Synonyms	B-cell surface antigen CD40, Bp50, CD40L receptor, CD40, Tnfrsf5, CDw40, GP39, HIGM1, IGM, IMD3, TBAM
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse CD40
Isotype	IgG
Purity	Affinity purification
Predicted MW.	32 kDa
Observed MW.	45 kDa
Uniprot ID	P27512, Q4QQW2

Applications

Applications	Species	Dilution	Positive Tissue
WB	Mouse, Rat	1: 500-1: 1000	splenitis, thymitis, pneumonia

Background

Cluster of differentiation 40, CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 is is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The TNFR-receptor associated factor adaptor proteins TRAF1, TRAF2, TRAF6 and possibly TRAF5 interact with this receptor serve as mediators of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.

Images

Western blot analysis of CD40 (GB11702)

at dilution of 1: 1000

Lane 1: A20 cell lysate

Lane 2: Mouse splenitis tissue lysate

Lane 3: Mouse thymitis tissue lysate

Lane 4: Rat splenitis tissue lysate

Lane 5: Rat pneumonia tissue lysate

Lane 6: Rat thymitis tissue lysate

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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