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Anti -CDKN2A/p16INK4a Rabbit pAb

價(jià)格: 在線(xiàn)咨詢(xún)
貨號(hào):
KT011714
產(chǎn)品規(guī)格:
100 μL
Applications:
IHC/IF
Species:
H
購(gòu)買(mǎi)數(shù)量:
產(chǎn)品詳情 操作說(shuō)明 注意事項(xiàng)

Product Information


Description

CDKN2A rabbit polyclonal antibody

Protein full name

Cyclin-dependent kinase inhibitor 2A

Synonyms

Cyclin-dependent kinase 4 inhibitor A, CDK4I,  p16-INK4a, Cdkn2a, P16ink4a

Immunogen

Recombinant protein corresponding to Mouse CDKN2A

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

P51480, Q9R0Z3




Applications


Applications

Species

Dilution

Positive Sample

IHC/IF

Human

1: 500-1: 2000

breast cancer, colon, lung cancer, ovarian cancer




Background


This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants.




Images


Picture 1.png

Immunohistochemistry of paraffin embedded human breast cancer using CDKN2A (GB111143) at dilution of 1:1000 (400x lens)

Picture 2.png

Immunohistochemistry of paraffin embedded human colon using CDKN2A (GB111143) at dilution of 1:1000 (400x lens)

Picture 3.png

Immunohistochemistry of paraffin embedded human lung cancer using CDKN2A (GB111143) at dilution of 1:1000(400x lens)

 

Picture 4.png

Immunohistochemistry of paraffin embedded human ovarian cancer using CDKN2A (GB111143) at dilution of 1:1000 (400x lens)

Picture 5.png


Immunofluorescence of paraffin embedded human breast cancer using CDKN2A (GB111143) at dilution of 1:500 (400x lens)

Picture 6.png


Immunofluorescence of paraffin embedded human colon using CDKN2A (GB111143) at dilution of 1:500 (400x lens)




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer.

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