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Product Information
Description |
TTK rabbit polyclonal |
Protein full name |
Dual specificity protein kinase TTK |
Synonyms |
Phosphotyrosine picked threonine-protein kinase, PYT, TTK, MPS1, MPS1L1 |
Immunogen |
KLH conjugated Synthetic peptide corresponding to Human TTK |
Isotype |
IgG |
Purity |
Affinity purification |
Subcellular location |
Cytoplasm, Nucleus |
Predicted MW. |
97 kDa |
Observed MW. |
97 kDa |
Uniprot ID |
P33981 |
Applications
Applications |
Species |
Dilution |
Positive Tissue |
WB |
Human |
1: 500-1: 1000 |
HeLa, MCF7, K562, Jurkat |
IHC |
Human |
1: 750-1: 1500 |
colon cancer, esophageal cancer |
Background
Mps1
family of kinases colocalizes with mitotic checkpoint proteins in
kinetochores and/or spindle pole bodies/centrosomes. TTK has been shown
to be a cell cycle-regulated kinase displaying maximum activity during M
phase. Its kinase activity is required for proper chromosome
segregation during mitosis through its involvements in
microtubule-chromosome attachment error correction and the mitotic
checkpoint.
Images
|
Western blot analysis of TTK (GB111371) at dilution of 1: 1000 Lane 1: Hela cell lysate Lane 2: MCF7 cell lysate Lane 3: K562 cell lysate Lane 4: Jurkat cell lysate |
|
Immunohistochemistry analysis of paraffin-embedded human colon cancer using TTK (GB111371) at dilution of 1: 750 |
|
Immunohistochemistry analysis of paraffin-embedded human esophageal cancer using TTK (GB111371) at dilution of 1: 750 |
Storage
Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .
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