Anti -P35 Rabbit pAb

價格：在線咨詢

貨號：

KT011836

產(chǎn)品規(guī)格：

100 μL

Applications：

Species：

M,R

品牌：

萬物

購買數(shù)量：

立即詢價在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項

Product Information

Description	P35 rabbit polyclonal antibody
Protein full name	Cyclin-dependent kinase 5 activator 1
Synonyms	CDK5 activator 1, Cyclin-dependent kinase 5 regulatory subunit 1, TPKII regulatory subunit, Tau protein kinase II 23 kDa subunit, Cdk5r1, CDK5P35, Neuronal CDK5 activator
Immunogen	Recombinant protein corresponding to Mouse P35
Isotype	IgG
Purity	Affinity purification
Predicted MW.	34 kDa
Observed MW.	35 kDa
Uniprot ID	P61809, P61810

Applications

Applications	Species	Dilution	Positive Sample
WB	Mouse, Rat	1: 500-1: 1000	hippocampus, brain, spinal cord, cerebellum

Background

Cyclin dependent kinase-5 (Cdk5), is an atypical but essential member of the Cdk family of proline-directed serine/threonine kinases. CDK5R1 encodes p35, a specific activator of the serine/threonine kinase CDK5, which plays a central role in neuronal migration and differentiation during central nervous system development. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form.The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location.

Images

Western blot analysis of P25 (GB111614) at dilution of 1: 500

Western blot analysis of P35 (GB111614) at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer	PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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