Anti -TLS/FUS Rabbit pAb

價格：在線咨詢

貨號：

KT012113

產品規(guī)格：

100ul

Applications：

IHC/IF

Species：

品牌：

萬物

購買數(shù)量：

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產品詳情操作說明注意事項

Product Information

Description	FUS rabbit polyclonal antibody
Protein full name	RNA-binding protein FUS
Synonyms	Protein pigpen, Fus, 75 kDa DNA pairing protein, ALS6, FUS CHOP, FUS1, POMp75, Fusion (involved in t(12;16) in malignant liposarcoma), hnRNP P2, Fusion gene in myxoid liposarcoma, Heterogeneous nuclear ribonucleoprotein P2, Oncogene TLS
Immunogen	Recombinant protein corresponding to Mouse FUS
Isotype	IgG
Purity	Affinity purification
Subcellular location	Nucleus
Uniprot ID	P56959

Applications

Applications	Species	Dilution	Positive Sample
IHC/IF	Mouse	1: 800-1: 2000	brain, pancreas, Skeletal muscle

Background

FUS (also named TLS and POMp75) belongs to the RRM TET family. FUS may play a role in the maintenance of genomic integrity; it binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. FUS is also an RNA-binding protein, and its links to neurodegenerative disease proffer the intriguing possibility that altered RNA metabolism or RNA processing may underlie or contribute to neuron degeneration. FUS may be a cause of angiomatoid fibrous histiocytoma (AFH) and is implicated in certain forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementias (FTDs) such as frontotemporal lobar dementia with ubiquitin inclusions (FTLD-U).

Images

	Immunofluorescence of paraffin embedded mouse brain using FUS (GB111365) at dilution of 1:1000 (400x lens)
	Immunofluorescence of paraffin embedded mouse pancreas using FUS (GB111365) at dilution of 1:1000 (400x lens)
	Immunofluorescence of paraffin embedded mouse Skeletal muscle using FUS (GB111365) at dilution of 1:1000 (400x lens)

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

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