Anti -NFAT4/NF-ATc3 Rabbit pAb

價(jià)格：在線咨詢

貨號(hào)：

KT012133

產(chǎn)品規(guī)格：

100ul

Applications：

IHC/IF

Species：

H/H

品牌：

萬(wàn)物

購(gòu)買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說(shuō)明注意事項(xiàng)

Product Information

Description	NFAT4/NF-ATc3 rabbit polyclonal
Protein full name	Nuclear factor of activated T-cells, cytoplasmic 3
Synonyms	NFATc3, NFATx, T-cell transcription factor NFAT4, NF-AT4, NF-AT4c, NFATC3
Immunogen	Recombinant protein corresponding to Mouse NFAT4/NF-ATc3
Isotype	IgG
Purity	Affinity purification
Subcellular location	Cytoplasm, Nucleus
Uniprot ID	Q12968

Applications

Applications	Species	Dilution	Positive Tissue
IHC	Human	1: 500-1: 2000	colon cancer
IF	Human	1: 250-1: 500	colon cancer

Background

NFATC3 (nuclear factors of activated T cells) proteins are a family of transcription factors originally identified as mediators of activation of cytokine genes in response to antigenic stimulation of T cells.NFATC3 is widely expressed being found in DP thymocytes, CD4+ T cells, smooth muscle cells, Schwann cells and mast cells. NFATC3 regulates gene transcription as part of a NFATC transcription complex. It is normally cytoplasmic and phosphorylated. Upon a rise in intracellular Ca+2, dephosphorylation occurs via calcineurin, and NFATC3 enters the nucleus. Human NFATC3 is 1075 amino acids in length. It contains a calcineurin binding site (aa 109?114), two nuclear localization sites (aa 273?275 and 686?688), one nuclear export site (a 1032?1041) and an RH domain that binds DNA (aa 433?592). There are multiple isoforms with different tissue expression profiles. Over a 900?1035, human NFATC3 shares 93% a identity with mouse NFATC3. The calculated molecular weight of NFATC3 is 115 kDa, but the post-modified protein is about 130-170 kDa .

Images

Immunohistochemistry analysis of paraffin-embedded human colon cancer using NFAT4/NF-ATc3 (GB111028) at dilution of1: 1000

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer .

凡合肥萬(wàn)物生物科技有限公司銷售的產(chǎn)品均有嚴(yán)格的質(zhì)量保證。如發(fā)現(xiàn)產(chǎn)品存在包裝規(guī)格疑問(wèn)，請(qǐng)于收貨之日起七日內(nèi)向我公司總部或當(dāng)?shù)剞k事處提出，并請(qǐng)保證該產(chǎn)品，以備本公司進(jìn)行核對(duì)檢驗(yàn)。如果發(fā)現(xiàn)有質(zhì)量問(wèn)題，請(qǐng)于收貨后一月內(nèi)保留產(chǎn)品50%以上的量，以便本公司回收產(chǎn)品進(jìn)行質(zhì)檢，確認(rèn)產(chǎn)品質(zhì)量。如逾期，則視為已經(jīng)對(duì)本公司產(chǎn)品進(jìn)行驗(yàn)收。聲明：如發(fā)生產(chǎn)品索賠事宜，本公司僅在產(chǎn)品價(jià)格范圍內(nèi)酌情賠償，恕不接受超出產(chǎn)品價(jià)格范圍之賠償。客戶在使用過(guò)程中有任何技術(shù)問(wèn)題可以撥打技術(shù)售后服務(wù)電話我們隨時(shí)給予解答。

合肥萬(wàn)物生物科技有限公司

客服熱線：400-1016-218

QQ：355185756

地址：安徽省合肥市高新區(qū)黃山路602號(hào)合肥國(guó)家大學(xué)科技園A401室