Anti -Histone H3.3 Rabbit pAb

價格：在線咨詢

貨號：

KT012150

產品規(guī)格：

Applications：

Species：

H/M/R

品牌：

萬物

購買數量：

立即詢價在線咨詢 400-1016-218

產品詳情操作說明注意事項

Product Information

Description	Histone H3.3 rabbit polyclonal antibody
Protein full name	Histone H3.3
Synonyms	H3F3A, H3.3A, H3F3, H3 histone, family 3A, H3 histone family member 3A
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse Histone H3.3
Isotype	IgG
Purity	Affinity purification
Predicted MW.	15 kDa
Observed MW.	17 kDa
Uniprot ID	P84243, P84244, P84245

Applications

Applications

Species

Dilution

Positive Tissue

Human,

Mouse, Rat

1:500-1:1000

lung, brain

Background

Histone H3.3 is a protein that in humans is encoded by the H3F3A gene.Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Images

Western blot analysis of Histone H3.3 (GB11026) at dilution of 1: 500

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.

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