Anti - SIRT1 Rabbit pAb

價(jià)格：在線咨詢

貨號：

KT012158

產(chǎn)品規(guī)格：

100 μL

Applications：

IHC/IF

Species：

H,M,R

品牌：

萬物

購買數(shù)量：

立即詢價(jià) 在線咨詢 400-1016-218

產(chǎn)品詳情操作說明注意事項(xiàng)

Product Information

Description	SIRT1 rabbit polyclonal antibody
Protein full name	NAD-dependent protein deacetylase sirtuin-1
Synonyms	SIR2L1,SIR2,hSIR2,SIR2alpha,Sirtuin 1
Immunogen	KLH conjugated Synthetic peptide corresponding to Mouse SIRT1
Isotype	IgG
Purity	Affinity purification
Subcellular location	Nucleus, Cytoplasm
Uniprot ID	Q923E4, Q96EB6

Applications

Applications	Species	Dilution	Positive Sample
IHC/IF	Human, Mouse, Rat	1: 500-1: 2000	testis, tonsil

Background

NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Serves as a sensor of the cytosolic ratio of NAD+/NADH which is altered by glucose deprivation and metabolic changes associated with caloric restriction.

Images

Picture 1.png

Immunohistochemistry of paraffin embedded human tonsil using SIRT1 (GB11171) at dilution of 1:1000 (400x lens)

Picture 2.png

Immunohistochemistry of paraffin embedded mouse testis using SIRT1 (GB11171) at dilution of 1:1000 (200x lens)

Immunohistochemistry of paraffin embedded rat testis using SIRT1 (GB11171) at dilution of 1:1000 (200x lens)

Storage

Storage	Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer	PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.

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